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Derek Lowe @Dereklowe Massachusetts

Drug discovery chemist and blogger Note: all opinions, choices of topic, etc. are strictly my own – I don’t in any way speak for my employer (or anyone else).

75 Following   31,223 Followers   19,522 Tweets

Joined Twitter 11/14/08


It's not gone, folks. I know we wish it were. But it's a dangerous time to indulge in magical thinking. Virus doesn… https://t.co/pT4k1n05S4
Retweeted by Derek Lowe
5/30
2020
@Dereklowe Worth mentioning that ongoing RCT on famotidine was forced to include HCQ because of initial hype on Chl… https://t.co/ulvC2KEfk4
Retweeted by Derek LoweWhen @Dereklowe writes an entire piece on work you've been a part of, that's a good day! Two notes: 1. Huge collabo… https://t.co/Nsj7uM3ELR
Retweeted by Derek LoweFor those photoredox reactions that absolutely need to be hosed down with photons! Impressive, but I'm curious abou… https://t.co/HIGRIn5hQECould some of the worse clinical features of SARS-CoV2 infection be tied to histamine release? A new preprint study… https://t.co/lZT9zXPKw7 @charleslbrooks @eriklindahl @Dereklowe Easily churning out unreliable results from canned software and then leavin… https://t.co/lIGD9tlD4k
Retweeted by Derek Lowe @Dereklowe As I tweeted on March 30, reports of docking results without experimental validation have no value. Pret… https://t.co/fa1iTiHWGn
Retweeted by Derek Lowe
5/29
2020
Update! This is a set of (at least) EIGHT papers, from different authors, different hospitals, different cancers, d… https://t.co/grcaEE5tEI
Retweeted by Derek LoweYou're not going to offset making America hostile to global talent with a capital gains tax cut. My gods.
Retweeted by Derek LoweNature: a wild lady slipper orchid (Cypripedium acaule). Growing not far from a peat bog where pitcher plants are f… https://t.co/JCyBpXbLeZConspiracy theorists today declared I am: a robot, an actor, a Moderna employee, an employee of their competitor(s)… https://t.co/0zfgM4HZfW
Retweeted by Derek Lowe @curiouswavefn Agreed! But I wonder if the adjective can ever be rehabilitated at this point. So many grifters and… https://t.co/Da5xFpqcchCan we calculate our way to new coronavirus drugs? Some things that make this less feasible than one would like: https://t.co/6CzGwAiiG4posted this morning: the https://t.co/SwQMUN9fs6 listing for $MRNA's phase 2 coronavirus vaccine study https://t.co/GIHXgLLGw3
Retweeted by Derek LoweWhy did #CDC this weekend drop cautions about choirs and "congregant singing, chanting and reciting" from its guide… https://t.co/rdtWljKMNO
Retweeted by Derek Lowe>@statnews has been updating our extensive Covid-19 drug and vaccine tracker. Did we miss something important? Hara… https://t.co/eInRtIrUFC
Retweeted by Derek Lowe". . .there is always a well-known solution to every human problem — neat, plausible, and wrong." H. L. Mencken, in… https://t.co/XI454uc3TP
5/28
2020
Nature: Iris cristata. Low-growing, spreading, and all blooming at once! https://t.co/Gm5kRCR1WY @Hoytster @stephaniekays @edit_susan I'm awaiting the results of controlled trials - we'll see then if it has an effect. But not before.Just published @nature: 2 papers on #COVID19 patient-derived monoclonal antibodies (mAbs) 1. 2 mAbs from 1 patient… https://t.co/DV3KcnmGqn
Retweeted by Derek LoweNew: Dr. Anthony Fauci tells me negative data on hydroxychloroquine is now “quite evident”.: “I'm not so sure tha… https://t.co/matsdsg789
Retweeted by Derek Lowe @RobertDancer01 Military explosive research is @JJSabatini's game, you will not be surprised to learn. Climbing up… https://t.co/an2lrPaDFY @esclasico And at reflux temperatures, to boot. Nope, don't wanna.Hard, hard pass on this one. If a compound is this resistant to oxidation, I’m going to respect its wishes. https://t.co/Uh1pQiiPD4TY @FinancialTimes @hannahkuchler for speaking with me. To get a Covid vaccine by '21 requires sequentially hitti… https://t.co/BRpH1AJkOD
Retweeted by Derek LoweFrance halts hydroxychloroquine use for COVID-19 cases: govt via AFP
Retweeted by Derek LoweVery nice thread: https://t.co/rWYS1SIoYc#COVID19 Fascinating work from @Baric_Lab describing a striking gradient of #SARSCoV2 infection w/ higher ACE2 expr… https://t.co/O7PuhcBCIX
Retweeted by Derek Lowe
5/27
2020
I know the $MRNA market cap is nuts. I know they're attempting to make the impossible possible. I understand the od… https://t.co/tqsTgOm0JJ
Retweeted by Derek LoweMerck CEO Ken Frazier offers a refreshing breath of honesty when needed regarding #COVID19 vaccines… https://t.co/ZE14grXHcV
Retweeted by Derek LoweA new roundup of the top coronavirus vaccine candidates, with the latest news and some new additions. It's a long p… https://t.co/UTXVwHa2egI feel a bit like an Onion-style headline: "Area Man Realizes That He's Paid For Worse Haircuts Than the Ones He's Been Giving Himself"Merck has licensed Ridgeback's antiviral EIDD-2801 (discovered by Emory, owned by Ridgeback for...2 months?). Here'… https://t.co/mYHC51lrJz
Retweeted by Derek LoweThe #covid19 effect, driven by investors who have no idea how this will play out commercially: $MRK +3.2% https://t.co/ACJFSLypSh
Retweeted by Derek LoweHe experienced a severe reaction to Moderna’s Covid-19 vaccine candidate. He’s still a believer… https://t.co/0T1E9ckJFK
Retweeted by Derek Lowe @adamfeuerstein It's sad, all this stroking and flattering that Trump requires of anyone around him. It demeans the… https://t.co/pPA1fffuX4
5/26
2020
@WHO @DrTedros @WHOAFRO @MoetiTshidi This is big news! @WHO is pausing the chloroquine/hydroxychloroquine arm of th… https://t.co/wLQHZxXlsA
Retweeted by Derek Lowe @nsokolsky @HelenBranswell You have the wrong idea about the word "developing", I'm afraid. We do not yet know if e… https://t.co/pHlTJW5TrdMore than 90 vaccines are being developed against SARS-CoV-2 across the world. At least six groups have begun injec… https://t.co/V8dmWV3tXd
Retweeted by Derek LoweSo tired of reading articles that project #Covid19 vaccine could be ready in a few months or a year without the key… https://t.co/VOJBDCfyvX
Retweeted by Derek Lowe
5/25
2020
for your weekend #longreads, this is a pretty good article about the Ch/ar/les Li/eb/er case and its chilling effec… https://t.co/KgIwZij6gs
Retweeted by Derek LoweIt's clear that we're running an experiment this weekend involving a large population. If #covid19 doesn't spike in… https://t.co/VIoNimXB5V
Retweeted by Derek Lowe"Conspiracy theorists' skepticism is a bottomless, never-ending pit of skepticism about anything related to the off… https://t.co/BkzcXnISRz
Retweeted by Derek LoweExcellent interview with Oxford #COVID19 vaccine project leader Professor Adrian Hill https://t.co/kCyeHCPmHV He… https://t.co/7pId84z6jo
Retweeted by Derek Lowe
5/24
2020
The 18-inch mirror assembly ready to start packing up for transport. 6oz can of bug repellent for scale: https://t.co/nVBrhZeKgkNature: looks like a good night for astronomy! One of tonight’s targets: the “Box” galaxies in Coma Berenices. Have… https://t.co/S6gF0ovNiMHonest question: how many of the rushed papers for #COVID19 drug predictions have led to experimental testing and s… https://t.co/8baKirqI7d
Retweeted by Derek Lowe @jaybradner Journal of Chemical Information and YodelingOh joy https://t.co/h8CPS8sE0o @Tom_Maguire I use SkySafari - the Pro version is a terrific help during an observing session, and I can even use i… https://t.co/Alqjd7lq9SThe optics of these $MRNA insider sales probably are going to look "terrible". Use tax payer funding to run a trial… https://t.co/xqh0Z825ar
Retweeted by Derek LoweThere have been claims that #COVID19 has acquired mutations leading to more transmissible strains. We formally test… https://t.co/ClASIQKtqM
Retweeted by Derek Lowe @rauchtate @mikeprime9 Boston suburbs - my sky is better than it might be, but still too bright. @kkearns 18 inch Dobsonian is my current scope! It can indeed show you a lot - after a while searching out faint st… https://t.co/cVVuUeFmSdThis does not bode well at all. https://t.co/RMdYjdslwgI finished reading the Remdesivir trial If you want my thoughts you will have to read this thread [Thread] https://t.co/GqA30lCOLI
Retweeted by Derek Lowe @mikeprime9 Naked-eye visible in this current configuration, at least after it gets dark enough (and if you have a… https://t.co/t6Tnwpy24sNature: if you can see bright Venus low in the West as it’s getting dark, try looking through binoculars. It’s actu… https://t.co/0baboEJYif
5/23
2020
In this double-blind RCT in 1063 adults hospitalized with #COVID19, a 10-day course of intravenous remidesivir was… https://t.co/KTacwShInT
Retweeted by Derek LoweExclusive: U.S. plans massive coronavirus vaccine testing effort to meet year-end deadline https://t.co/Vjwwr0w0Z8
Retweeted by Derek LoweA vaccine developed in China appears to be safe and may protect people from the new coronavirus -- but there are ca… https://t.co/qqvEL6TBtC
Retweeted by Derek LoweSweden kept its primary schools open all along so you'd think its scientists can tell us a lot about COVID-19 trans… https://t.co/L6WxADsdsb
Retweeted by Derek Lowe @nuala_00 This will have to be hashed out in light of efficacy data - it's going to be a balancing act, most likely… https://t.co/0vc9cJXYU4Phlow CEO answers @pharmalot's questions re: criticism of his record, plans for a drug ingredient stockpile, and a… https://t.co/GIXKfSjO4v
Retweeted by Derek Lowe @Chemjobber A battle between the Quines, the Quins, and the Queens. . .Is it time to draw the curtain on the whole idea of using hydroxychloroquine, with or without azithromycin, etc.? T… https://t.co/XRumiFoTr8 @DelawareHere Oxford's AAV is not one that human have antibodies to, if that's what you mean. But it is likely that… https://t.co/bQUA8DYuPoFor those who missed it yesterday afternoon, a new paper on the (unusual) human immune response to the current viru… https://t.co/EA7F5Glb4iIt's also key to note (as the paper does) that we don't yet know the correlates for human immunity: what titer of n… https://t.co/p5SBMbQgBrHuman vaccine data from CanSino in The Lancet. First read is that T cells and neutralizing antibodies are definitel… https://t.co/ZTc4ZeVzzEIncidentally, it’s also why I think the adeno vaccines may be underestimated. Despite a reasonable level of focus… https://t.co/LPTBIey04S
Retweeted by Derek LoweData trumps hope in this large (but non controlled/randomized) study of hydroxychloroquine in 96,000 hosp patients… https://t.co/IKi34wvPlm
Retweeted by Derek Lowe“We want this to go away. Lord knows I understand that. But the problem is that we don't have any of those magic bu… https://t.co/AMztYxx1gH
Retweeted by Derek Lowe
5/22
2020
Together with this Cell paper, more data has suggested IFNβ a potential #covid19 antiviral. Phase 2 trial shows ra… https://t.co/pckKe5FOI5
Retweeted by Derek LoweA chance for the biopharma industry to help redeem its reputation - if we don't blow it: https://t.co/eLABtEXtUrA new paper suggests that the coronavirus may be setting off a unique (and uniquely imbalanced) immune response, ev… https://t.co/eRrEGoffs0 @michael_gilman I was wondering if you'd have that one on the list! A favorite, for sure. Any thoughts on "Riddley… https://t.co/BCE6t7ual2#COVID19 One of the most encouraging sign in U.S. is the decline in testing positivity rate. Unfortunately the dat… https://t.co/plkhOK9PV1
Retweeted by Derek LoweI wrote an entire book about how people bullshit using numbers and statistics, it hasn't even come out yet, and I a… https://t.co/YRp2c1t63T
Retweeted by Derek Lowe @matthewherper I see what you mean - just saying that is a non-sequitar. We need as many different vaccine candidat… https://t.co/a8CxKNdW6F @matthewherper Go on - I may be ready to agree with you here, but I'd like to hear your thoughts!Astra received more than $1B from BARDA today to help scale up manufacturing of the Oxford vaccine. Says they have… https://t.co/Vx5Km2ZVkd
Retweeted by Derek Lowe““You’ve got to be kidding me,” said ⁦@ashishkjha⁩. “How could the CDC make that mistake? This is a mess.” https://t.co/JX6vEq5iqa
Retweeted by Derek Lowe
5/21
2020
A lot of government reports from European countries on seroprevalence to SARS-CoV-2 this week and they all show the… https://t.co/L4yBYHnfG7
Retweeted by Derek LoweImmune modulation of #COVID19: a new review today @TheLancetRheum on the pathways and tool kit of drugs that are in… https://t.co/rBg0f3aQUF
Retweeted by Derek LoweSinovac's #Covid19 vaccine is in human trials, but investors aren't benefiting, @damiangarde writes. Because the st… https://t.co/EfCP3I3aoP
Retweeted by Derek Lowe @ABertheim @sciencescanner Here's one: https://t.co/94GvUl4l4u https://t.co/K0oJ1gAE4CMore on the Florida coronavirus numbers: is there any reason to trust the state's reporting, at this point? https://t.co/RebFbzrx5cI've been thinking... #naturalproduct #biosynthesis (& many other) figures are begging to be shown in action, so I… https://t.co/hruf7w81RT
Retweeted by Derek LowePfizer reports a shortage of Azithromycin due to increased demand for the drug https://t.co/XqYzazkAKp https://t.co/bDuADuPRj6
Retweeted by Derek LoweThis group has access to a lot of monkeys. They also showed monkey infected with the virus once were resistant to r… https://t.co/NbaMbRcTEh
Retweeted by Derek LoweThis is true - but the earlier hype led to clinical trials that couldn't even get off the ground unless they includ… https://t.co/JfwSLBQ8CD @bkschwartz @zbiotech I think a bigger problem is that neither Trump nor his supporters actually care about any of… https://t.co/qDbtAjcBRubit of difference between these two statements from dr slaoui last friday vs $MRNA today “This data made me feel e… https://t.co/5ZhreKwxsU
Retweeted by Derek Lowe#COVID19 $INO One the weaker pre-clinical dataset among published data from leading vaccine candidates: only mice &… https://t.co/AdyIMMMfKH
Retweeted by Derek LoweThe Man Betting $1 Billion That Pfizer Can Deliver A #COVID19 Vaccine By This Fall. $PFE $BNTX https://t.co/OJZLUl9fb9
Retweeted by Derek LoweWhole books could be written on the Wild West that is Covid data • Weeks-long backlogs of deaths or cases being cas… https://t.co/ozcFyjDOwz
Retweeted by Derek LoweIt was 3 weeks ago that NIH press released remdesivir. Since then, 100,000+ more people worldwide (30,000 in US) h… https://t.co/rMqPH4kE7W
Retweeted by Derek LoweHow to develop a vaccine to achieve immunity vs #COVID19, @sciam, good summary of the challenges but also accelera… https://t.co/ykNFnycl6x
Retweeted by Derek LoweToday, this new preprint from John Ioannidis (of "Most Published Research Findings Are False" fame) went online Al… https://t.co/FFhMAtcYhK
Retweeted by Derek Lowe
5/20
2020

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