Sign in with Twitter

Username:

Jacob Corn @jcornlab Zurich, Switzerland

Genome editing, functional genomics, and cells figuring out how to eat themselves without dying. Professor of Genome Biology at ETH Zürich.

380 Following   3,674 Followers   2,402 Tweets

Joined Twitter 2/23/14


Thanks for the commentary! This is a great explainer, and far more clear than I could ever write. I especially love… https://t.co/q6Bjzy59N6
8/11
2020
This fall I'm virtually teaching my #freshman #genetics and #cellbiology lectures @ETH_en. Abt 500 students. I norm… https://t.co/keue9UggmVI'm back from a two week hike on the #Swiss #ViaAlpina with my family (hence Twitter silence). Our 18 month old dau… https://t.co/B9qatkMr8H
8/6
2020
@UoM_GEU @CellReports Great question! It doesn't take a lot of fetal globin to prevent sickling. And adult globin i… https://t.co/jTraGmpIlWEvery time I give a talk about #SickleCell #CRISPR, someone asks why fetal globin goes up after editing. New paper… https://t.co/jy5X5S7klg
8/5
2020
Our human DNA damage network paper is finally out! See thread for updates on what changed since we posted our BioRx… https://t.co/Jbq6IyyoZ3
Retweeted by Jacob Corn @gracescience I'd love to have you visit! Show you some amazing 🇨🇭🧀🍫🏞️🧪.
7/9
2020
Stop whatever you're doing and read this. Actually, better get a tissue, first. Strength, love, perseverance. Amazi… https://t.co/jlMdKQ7sQdToday we report in @nature, in collaboration with the labs of Joseph Mougous and @VamsiMootha, the development of a… https://t.co/53HtS8ogJD
Retweeted by Jacob CornMy thoughts on the recent #XLMTM #GeneTherapy deaths following high dose #AAV 👇 https://t.co/f0AWJJSMa4
Retweeted by Jacob Corn
7/8
2020
@crisprscan @josefra1975 Thanks! It's the work of fearless grad student Alan Wang. He did everything from the bioch… https://t.co/dGpFHj9YxO
7/1
2020
How does in vitro sticky Cas9 get pushed off genomes in cells? Grad student Alan Wang found that the FACT chromatin… https://t.co/z1pZQyUajH
6/30
2020
The delivery challenge: fulfilling the promise of therapeutic genome editing https://t.co/J1gAM1V2TA https://t.co/yLYczQ0Rte
Retweeted by Jacob Corn
6/29
2020
Postdoc position! Please RT. We are a diverse group of scientists @UCBerkeley leveraging interdisciplinary strategi… https://t.co/GTWvhoKlL7
Retweeted by Jacob CornWe are seeking a Scientist and Lab Manager interested in developing and applying molecular technologies at the inte… https://t.co/ghO5PgsWNu
Retweeted by Jacob CornDear scientist friends all over the world, we are trying to ask for more funding and better conditions to do our j… https://t.co/yJB62kFhix
Retweeted by Jacob Corn
6/18
2020
@crisprscan Oops - I mean to attach a pic of the ad so deleted/reposted. Sorry to break your retweet!My lab has an opening available immediately for a postdoc working on editing/engineering of human blood cells. Swit… https://t.co/kSLlNiukQn
6/10
2020
A short Spotlight on the emerging field or ER-phagy. How cells do eat their own protein's, lipid's and sugar's fact… https://t.co/jsUdSbzTR3
Retweeted by Jacob Corn
6/5
2020
#DNArepair is a big deal. Problems in repair cause all kinds of disease, and there's a lot to learn. The website fo… https://t.co/0uvys0fMGi
6/4
2020
It was great fun for my group to make our own small contribution to this exciting paper from the labs of… https://t.co/ek35BePVVv
6/2
2020
Are you in #Switzerland & getting started with #CRISPR editing, txn regulation, or even whole-genome screening? Or… https://t.co/j5r3s12wZq
5/29
2020
#Switzerland is gradually opening up. @ETH_DBIOL labs have been operating at limited capacity for a few weeks now.… https://t.co/f0fZOIhFVo
5/28
2020
Want more #CRISPR HDR with less mess than nocodazole? A small molecule you can throw on T cells & more to increase… https://t.co/wjOqGuYrAF
5/2
2020
There's no price better than free! https://t.co/0MAp6lsQDM
4/28
2020
Interested in trying discover-seq to find #CRISPR off-targets in your own lab? Check out the step-by-step from… https://t.co/KcRcCCeLRv
4/22
2020
Our tips and tricks for scalable and combinatorial Perturb-seq screens out today in Nature Biotechnology! Something… https://t.co/kDjawOiHS8
Retweeted by Jacob Corn
3/30
2020
Tracking #COVID19 in Switzerland in real time. Short (<1 min) survey for everyone (sick+not sick) to take daily. Gr… https://t.co/2LALGOelVA
Retweeted by Jacob Corn
3/29
2020
Log entry. Wet lab now dry lab since 1 week. Slack #papers channel active. Server CPU load high. Daily coffee zoom… https://t.co/1XvspOBAsa
3/27
2020
Very excited to share our 1⃣st publication from the lab - the development of near PAMless CRISPR-Cas9 variants. Hu… https://t.co/yxutfbehia
Retweeted by Jacob Corn
3/26
2020
Our paper is out on @biorxivpreprint describing our SARS CoV2-human protein-protein interaction map and drug predic… https://t.co/o48H4DXsLg
Retweeted by Jacob Corn
3/23
2020
Now Online Foundations of ER-phagy regulation https://t.co/aKvtd4zolo
Retweeted by Jacob Corn
3/21
2020
A great opportunity to work at the forefront of genome editing! https://t.co/UqIrAr472N
3/13
2020
@OlzmannLab @amosliang2 Couldn't have done it without you! Your support of Emily was incredible and generous.Did you know that cells eat their own endoplasmic reticulum? How do they even do that?? Postdoc @amosliang2 and PhD… https://t.co/JUzim1eTeW
3/10
2020
Finally our CRISPR screening approach in organoids is out! Hope other labs will be able to take advantage of this a… https://t.co/UZ1HEsOItv
Retweeted by Jacob Corn
3/6
2020
So we ran this genome-wide siRNA screen for prion modifiers, and found a bunch of exciting hits. They all knocked d… https://t.co/fnCA4MThKx
Retweeted by Jacob Corn
2/22
2020
.@jcornlab lab is hiring postdocs for his new lab in Zurich. "Great science, great people, and great views."… https://t.co/nxOdaradi0
Retweeted by Jacob Corn
2/11
2020
We also report improving the targeting accuracy of base editors through the detection (w/o WGS) and minimization of… https://t.co/pa7XoZFNPL
Retweeted by Jacob Corn
2/10
2020
Airline status apocalypse! I've cut travel to near-zero since my daughter was born. This year I go from #Premier1khttps://t.co/9tdg0OmIQ2
2/8
2020
A promising step on the road to using #crispr for engineered cell therapies and to treat #geneticdisease! https://t.co/vSSahXLXzo
2/7
2020
We wrote the review that I wished I'd had when I started my PhD in gene regulation & genomics! Read for our take on… https://t.co/R81LNxn3qB
Retweeted by Jacob CornWhere is Kandersteg, you might ask? Here! https://t.co/00wqFp2Luk
1/29
2020
@davidrliu @SuperScienceGrl "It's hard to start DNA."We wrote a review about how cells respond to DNA double-strand breaks in #mitosis 👇 https://t.co/bOwBpLHqYJ
Retweeted by Jacob CornAn incredible resource for patients, doctors, and researchers. https://t.co/IyHX0hFTvTI'm on my way to Kandersteg for the @NCCR_RNADisease retreat. The program looks super interesting! Looking forward… https://t.co/v99U7H5sviIs this why it seems like GTEx always says every gene of interest is expressed in the testis? Selection against dri… https://t.co/xQEI01QF5m
1/28
2020
Final date: 26-28 October. Confirmed speakers: J. Corn @jcornlab, K. Niakan @NiakanLab, K. Maxwell @theMaxwellLab,… https://t.co/m8gVRZyRxw
Retweeted by Jacob Corn
1/27
2020
The DNA in our bodies accumulates mutations as we age. We are studying how this somatic mutation rate varies across… https://t.co/GPZX81H7Vv
Retweeted by Jacob Corn
1/24
2020
@NucleaseLab Great idea!
1/23
2020
Happy to share our paper showing that temperate phages can drive the loss of CRISPR-Cas system. Great collaborative… https://t.co/W4gKAIzURR
Retweeted by Jacob Corn @BohacekLab @ZenobiWongLab Any time! @ZenobiWongLab Special Swiss touches: The two silver things on the bottom right side are sensors that figure out i… https://t.co/O0V6tox9fFHaving my lab next to the #bioengineering wizards in @ZenobiWongLab is something special. We provide the #espressohttps://t.co/VmI5rcTaPY
1/22
2020
@kim_vanuytsel @bloodgenes I'm blushing!
1/20
2020
@PhilippMarkolin We were surprised to see that ATF4 and all of its targets are *down* after beta globin reduction.… https://t.co/lOViU8i1vTEvery time I give a talk about #SickleCell #CRISPR, someone asks why fetal globin goes up after editing. The lab's… https://t.co/4mWvrEbRkJ
1/17
2020
The "Joining Forces Symposium" takes place again, in 2020 (21 January) on the topic “Organisation, Stability and En… https://t.co/Ch2CF0Y3e4
Retweeted by Jacob Corn @AkshaySharmaMD @pknoepfler @MerlinCrossley @JulesGrunewald @JSheltzer @DiMiccoLab @danielevanbauer @CRISPRjournalhttps://t.co/hwg79ugsiQJacob Corn explains in the ETH Zurich "Zukunftsblog" the potential of the CRISPR method and what it should absolute… https://t.co/AaDYTg4LNB
Retweeted by Jacob Corn
1/15
2020
Proud to announce that Acrigen is recruiting. Come join a great team working on anti-CRISPRs and gene editing! https://t.co/zDnf4Awpt4
Retweeted by Jacob Corn
1/11
2020
@antonioregalado This is the first I've heard that you wanted to talk with me. Sorry if I missed a call, email, or… https://t.co/S5jLXWbUHZ @antonioregalado Everyone in my lab, including me, was very surprised when Mark revealed that he knew about JK's wo… https://t.co/8OkN79q2fpThis editorial ignores that JK's actions were awful irregardless of #germline #CRISPR. He misled patients, falsifie… https://t.co/rxOQMA7ErF
1/3
2020
@UrnovFyodor Adding a + causes Gmail to ignore everything afterwards for delivery but retain it in the header. So f… https://t.co/01ytkNo353
1/2
2019
@UrnovFyodor @DocDellaire @doyonlab @jstarklab @RobinVSchendel @JulietteKamp @scekker In talks, I still use the bea… https://t.co/YAF34B1ZnF
12/16
2019
What does DNA repair have to do with #CRISPR genome editing? Absolutely everything! If you want to get up to speed,… https://t.co/YIFAtM5Cx7
12/3
2019
My lab is looking for a Bioinformatics Scientist to join our team and develop/apply computational methods in the ar… https://t.co/lLr7fzAEZz
Retweeted by Jacob Corn
12/2
2019
Grace Wilsey is one of 54 people in the world diagnosed with NGLY1 deficiency. Her father, @mattrwilsey, MBA ’08, i… https://t.co/NvDmvL5rMu
Retweeted by Jacob CornNew #preprint, co-corresponding with the wonderful @shaheenkabir! Our @CIRMnews funded project on modeling and pote… https://t.co/hrj2a5C9Pn
11/27
2019
Just 10 days left to apply for a tenured professorship in @ETH_DBIOL at @ETH. Looking for colleagues interested in… https://t.co/zP12Z8qH9DA co-regulation map of human proteome is able to capture the relationships between proteins that do not physically… https://t.co/7c8Awws6tm
Retweeted by Jacob Corn
11/20
2019
A rising tide lifts all boats! Here's to real cures for #geneticdisease rather than supportive care. There's a long… https://t.co/hrChbwLjjx
11/19
2019
Delighted to share our new preprint where we use chemogenomics to map the response to genotoxic agents: A genetic m… https://t.co/C0jSu77p7x
Retweeted by Jacob Corn @randall_platt @TreutleinLab @ETH_BSSE I was heartbroken to miss this. I wish @ETH_en would schedule inaugural lect… https://t.co/hD5uPH5IwA
11/18
2019
I can't wait to read this exciting preprint on HDR after genome editing. Finally, a deep analysis of many events! https://t.co/93tDBTtQNe
11/15
2019
Just finished a few weeks of teaching molecular genetics to almost 500 @ETH_en #undergrads. Very interactive, despi… https://t.co/FBACfsMclZGenome editing of the globin locus to induce fetal hemoglobin, the basis for our upcoming #GeneTherapy clinical tri… https://t.co/5HvrvuXDbg
Retweeted by Jacob CornI'm looking forward to an interesting day in #Bern! https://t.co/Z73GdahktY
11/13
2019
I've been a @dsgoodsell fanboy since I was a wee technician in @wysscoray lab many years ago. I'm giddy about his d… https://t.co/p3tqcmM1u6A reminder: "cluster sizes in a t-SNE plot mean nothing" https://t.co/GUe2BTFLEO #gi2019
Retweeted by Jacob CornOverly Honest Grant Writing Workshop (feel free to add)
Retweeted by Jacob Corn
11/9
2019
😮 https://t.co/IdCnrsQbdR
11/5
2019
To anyone who feels like the weight of their constant mistakes has irreparably hindered their progress (but especia… https://t.co/bvfX3KSSG5
Retweeted by Jacob CornThis is crazy cool. https://t.co/7BYJSk5Zoh
Retweeted by Jacob CornWe are currently making a humongous amount of Taq ligase (HiFi) for >900'000 reactions. If we end up with more than… https://t.co/BPQn3JoLDl
Retweeted by Jacob Corn @BiotechMongoose I think you would be surprised how many of us had dCas9-BirA*/APEX going prior to 2016 but didn't… https://t.co/UY5w2oPjW8 @GenomeStability @BioRender Have you found it worth the cost? We use Illustrator (institution site license) for gra… https://t.co/0FpFXtrCpS
11/2
2019
@AprilPawluk Strong verbs, short sentences. https://t.co/UnrXgixDk5
11/1
2019
Organizers + speaker lineup + always 70 degrees and partly sunny + infinite supply of superb dark roast = !!!… https://t.co/o5fEWOnPRQ
Retweeted by Jacob CornOur paper showing that NHEJ is dispensable for efficient error-prone editing of Cas9-induced breaks is out! Led by… https://t.co/CoFf73TSJ2
Retweeted by Jacob Corn
10/31
2019
(1/3) We are pleased to present the long-awaited structure of the Fanconi anaemia core complex, an E3 ligase involv… https://t.co/Rpu0uGTXOA
Retweeted by Jacob CornThis kind of Personalized Medicine is the future. Not subdividing big populations into slightly smaller populations… https://t.co/Hd8B0kGRZu
10/30
2019
ALWAYS USE MULTIPLE GUIDES TO CONFIRM YOUR PHENOTYPE. AND, DO A RESCUE EXPERIMENT FOR GENES YOU REALLY CARE ABOUT… https://t.co/9R8nnEITJg
Retweeted by Jacob CornIn support of @JohnDoench. This demonstration that a CRISPR-induced KO at the genetic level does not translate (sor… https://t.co/ORnUnDbPRF
Retweeted by Jacob Corn
10/29
2019
We have known that gene insertions (gene traps, P element hops, viral integrations) are often hypomorphic (not null… https://t.co/FjSAJRWRhF
Retweeted by Jacob CornI'm hiring! I have openings for two postdocs and a Cell Line Engineer (technician). Postdocs email me your CV and a… https://t.co/IvzsRgxseQ
10/28
2019
@antonioregalado @davidrliu @jason_pontin @EricTopol @Addgene Not my thoughts at all. The paper and the data are be… https://t.co/4dCxGeqGj6 @antonioregalado Oh, there are so many other motives to consider for *all* papers! Postdocs need jobs, grants need… https://t.co/6pXNNl07LX
10/22
2019

0