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Jacob Corn @jcornlab Zurich, Switzerland

Genome editing, functional genomics, and cells figuring out how to eat themselves without dying. Professor of Genome Biology at ETH Zürich.

348 Following   3,259 Followers   2,354 Tweets

Joined Twitter 2/23/14


The DNA in our bodies accumulates mutations as we age. We are studying how this somatic mutation rate varies across… https://t.co/GPZX81H7Vv
Retweeted by Jacob Corn
1/24
2020
@NucleaseLab Great idea!
1/23
2020
Happy to share our paper showing that temperate phages can drive the loss of CRISPR-Cas system. Great collaborative… https://t.co/W4gKAIzURR
Retweeted by Jacob Corn @BohacekLab @ZenobiWongLab Any time! @ZenobiWongLab Special Swiss touches: The two silver things on the bottom right side are sensors that figure out i… https://t.co/O0V6tox9fFHaving my lab next to the #bioengineering wizards in @ZenobiWongLab is something special. We provide the #espressohttps://t.co/VmI5rcTaPY
1/22
2020
@kim_vanuytsel @bloodgenes I'm blushing!
1/20
2020
@PhilippMarkolin We were surprised to see that ATF4 and all of its targets are *down* after beta globin reduction.… https://t.co/lOViU8i1vTEvery time I give a talk about #SickleCell #CRISPR, someone asks why fetal globin goes up after editing. The lab's… https://t.co/4mWvrEbRkJ
1/17
2020
The "Joining Forces Symposium" takes place again, in 2020 (21 January) on the topic “Organisation, Stability and En… https://t.co/Ch2CF0Y3e4
Retweeted by Jacob Corn @AkshaySharmaMD @pknoepfler @MerlinCrossley @JulesGrunewald @JSheltzer @DiMiccoLab @danielevanbauer @CRISPRjournalhttps://t.co/hwg79ugsiQJacob Corn explains in the ETH Zurich "Zukunftsblog" the potential of the CRISPR method and what it should absolute… https://t.co/AaDYTg4LNB
Retweeted by Jacob Corn
1/15
2020
Proud to announce that Acrigen is recruiting. Come join a great team working on anti-CRISPRs and gene editing! https://t.co/zDnf4Awpt4
Retweeted by Jacob Corn
1/11
2020
@antonioregalado This is the first I've heard that you wanted to talk with me. Sorry if I missed a call, email, or… https://t.co/S5jLXWbUHZ @antonioregalado Everyone in my lab, including me, was very surprised when Mark revealed that he knew about JK's wo… https://t.co/8OkN79q2fpThis editorial ignores that JK's actions were awful irregardless of #germline #CRISPR. He misled patients, falsifie… https://t.co/rxOQMA7ErF
1/3
2020
@UrnovFyodor Adding a + causes Gmail to ignore everything afterwards for delivery but retain it in the header. So f… https://t.co/01ytkNo353
1/2
2019
@UrnovFyodor @DocDellaire @doyonlab @jstarklab @RobinVSchendel @JulietteKamp @scekker In talks, I still use the bea… https://t.co/YAF34B1ZnF
12/16
2019
What does DNA repair have to do with #CRISPR genome editing? Absolutely everything! If you want to get up to speed,… https://t.co/YIFAtM5Cx7
12/3
2019
My lab is looking for a Bioinformatics Scientist to join our team and develop/apply computational methods in the ar… https://t.co/lLr7fzAEZz
Retweeted by Jacob Corn
12/2
2019
Grace Wilsey is one of 54 people in the world diagnosed with NGLY1 deficiency. Her father, @mattrwilsey, MBA ’08, i… https://t.co/NvDmvL5rMu
Retweeted by Jacob CornNew #preprint, co-corresponding with the wonderful @shaheenkabir! Our @CIRMnews funded project on modeling and pote… https://t.co/hrj2a5C9Pn
11/27
2019
Just 10 days left to apply for a tenured professorship in @ETH_DBIOL at @ETH. Looking for colleagues interested in… https://t.co/zP12Z8qH9DA co-regulation map of human proteome is able to capture the relationships between proteins that do not physically… https://t.co/7c8Awws6tm
Retweeted by Jacob Corn
11/20
2019
A rising tide lifts all boats! Here's to real cures for #geneticdisease rather than supportive care. There's a long… https://t.co/hrChbwLjjx
11/19
2019
Delighted to share our new preprint where we use chemogenomics to map the response to genotoxic agents: A genetic m… https://t.co/C0jSu77p7x
Retweeted by Jacob Corn @randall_platt @TreutleinLab @ETH_BSSE I was heartbroken to miss this. I wish @ETH_en would schedule inaugural lect… https://t.co/hD5uPH5IwA
11/18
2019
I can't wait to read this exciting preprint on HDR after genome editing. Finally, a deep analysis of many events! https://t.co/93tDBTtQNe
11/15
2019
Just finished a few weeks of teaching molecular genetics to almost 500 @ETH_en #undergrads. Very interactive, despi… https://t.co/FBACfsMclZGenome editing of the globin locus to induce fetal hemoglobin, the basis for our upcoming #GeneTherapy clinical tri… https://t.co/5HvrvuXDbg
Retweeted by Jacob CornI'm looking forward to an interesting day in #Bern! https://t.co/Z73GdahktY
11/13
2019
I've been a @dsgoodsell fanboy since I was a wee technician in @wysscoray lab many years ago. I'm giddy about his d… https://t.co/p3tqcmM1u6A reminder: "cluster sizes in a t-SNE plot mean nothing" https://t.co/GUe2BTFLEO #gi2019
Retweeted by Jacob CornOverly Honest Grant Writing Workshop (feel free to add)
Retweeted by Jacob Corn
11/9
2019
😮 https://t.co/IdCnrsQbdR
11/5
2019
To anyone who feels like the weight of their constant mistakes has irreparably hindered their progress (but especia… https://t.co/bvfX3KSSG5
Retweeted by Jacob CornThis is crazy cool. https://t.co/7BYJSk5Zoh
Retweeted by Jacob CornWe are currently making a humongous amount of Taq ligase (HiFi) for >900'000 reactions. If we end up with more than… https://t.co/BPQn3JoLDl
Retweeted by Jacob Corn @BiotechMongoose I think you would be surprised how many of us had dCas9-BirA*/APEX going prior to 2016 but didn't… https://t.co/UY5w2oPjW8 @GenomeStability @BioRender Have you found it worth the cost? We use Illustrator (institution site license) for gra… https://t.co/0FpFXtrCpS
11/2
2019
@AprilPawluk Strong verbs, short sentences. https://t.co/UnrXgixDk5
11/1
2019
Organizers + speaker lineup + always 70 degrees and partly sunny + infinite supply of superb dark roast = !!!… https://t.co/o5fEWOnPRQ
Retweeted by Jacob CornOur paper showing that NHEJ is dispensable for efficient error-prone editing of Cas9-induced breaks is out! Led by… https://t.co/CoFf73TSJ2
Retweeted by Jacob Corn
10/31
2019
(1/3) We are pleased to present the long-awaited structure of the Fanconi anaemia core complex, an E3 ligase involv… https://t.co/Rpu0uGTXOA
Retweeted by Jacob CornThis kind of Personalized Medicine is the future. Not subdividing big populations into slightly smaller populations… https://t.co/Hd8B0kGRZu
10/30
2019
ALWAYS USE MULTIPLE GUIDES TO CONFIRM YOUR PHENOTYPE. AND, DO A RESCUE EXPERIMENT FOR GENES YOU REALLY CARE ABOUT… https://t.co/9R8nnEITJg
Retweeted by Jacob CornIn support of @JohnDoench. This demonstration that a CRISPR-induced KO at the genetic level does not translate (sor… https://t.co/ORnUnDbPRF
Retweeted by Jacob Corn
10/29
2019
We have known that gene insertions (gene traps, P element hops, viral integrations) are often hypomorphic (not null… https://t.co/FjSAJRWRhF
Retweeted by Jacob CornI'm hiring! I have openings for two postdocs and a Cell Line Engineer (technician). Postdocs email me your CV and a… https://t.co/IvzsRgxseQ
10/28
2019
@antonioregalado @davidrliu @jason_pontin @EricTopol @Addgene Not my thoughts at all. The paper and the data are be… https://t.co/4dCxGeqGj6 @antonioregalado Oh, there are so many other motives to consider for *all* papers! Postdocs need jobs, grants need… https://t.co/6pXNNl07LX @UrnovFyodor @circuit_logic @GaetanBurgio I also would have accepted the paper. I might have asked for changes in w… https://t.co/Wld4PczHvC @UrnovFyodor @circuit_logic @GaetanBurgio Also, I'm very much in favor of company formation and David is excellent… https://t.co/w7yxhylmkd @UrnovFyodor @circuit_logic @GaetanBurgio I'm not naive. Spin is important to communicate our in-the-trenches work… https://t.co/G3NEZgIFnT @UrnovFyodor @circuit_logic @GaetanBurgio It's a good paper. Very creative, a nice parallel to CRISPEY. I'm looking… https://t.co/3W16GdWmS6The rarity of two homozygous parents is often used as an argument against germline editing. Read the story of one s… https://t.co/afwUkLgb1BPrime editing is here! I'm looking forward to trying this out. Super idea and thoroughly tested. Please calm down w… https://t.co/W99775meJk
10/22
2019
During the last five days I tried to quit drinking coffee. I'm sorry to anyone I talked to during that time I was n… https://t.co/Yn1jKiu49U
10/17
2019
Hi all, we’re still hiring! Great opportunity for PhD-level at the interface between cell biology, big data and com… https://t.co/iK1CDoTf2e
Retweeted by Jacob Corn
10/15
2019
If you are not an academic, this will seem insane If you are, you will wish to hire this guy. You can’t, though,… https://t.co/ThIbeJ3Wgg
Retweeted by Jacob Corn
10/14
2019
It's always good to have more tools in the toolbox when fighting for human health. Combining nicking with templated… https://t.co/OeWrlp3hr8My lab has been awarded an ERC Synergy grant, together with @LoizouJoanna and @SPJacksonGroup! We will use #CRISPRhttps://t.co/A0o3Gn6YrIThe first person with #SickleCell disease to be cured with #CRISPR #GenomeEditing shares her story on @NPR 🙏🏽… https://t.co/F5iLryMp6c
Retweeted by Jacob CornStarting Principal Investigator positions are open at CeMM, a place to do top science in a stimulating environment… https://t.co/LqRieK56S6
Retweeted by Jacob CornWhat does the academic job market look like? Do I need a CNS paper? (no) Do I need a K99? (no) How many application… https://t.co/a4O9oeBCR7
Retweeted by Jacob Corn
10/11
2019
#Zurich really shines in the fall. https://t.co/Ttw95f5N3Y
10/9
2019
I'm grateful to @snsf_ch for a new grant supporting my lab's work on #DNArepair during #CRISPR editing. And thanks… https://t.co/aElr6VJc8J...for those of you who missed the inaugural lecture of Jacob Corn @jcornlab on "CRISPR-Cas genome editing: from m… https://t.co/c5PVF6Oi2m
Retweeted by Jacob CornThe BioID cell map is so easy to browse. Kudos to the authors for making their data accessible. This is very hard t… https://t.co/5bCP6tZhylWhoah. I could explore through this dataset for days and never get bored. Incredible! https://t.co/nWxiU2OMow
10/8
2019
The ability to engineer our genome is becoming one of medicine's most powerful therapeutic arsenals. Here are my th… https://t.co/HQPXsUu5Gu
Retweeted by Jacob CornToday marks my final day at Editas Medicine ($EDIT). Thanks to current and former team members for 4 1/2 great yea… https://t.co/oAMX0HDAYw
Retweeted by Jacob CornIf you're in Zurich today and interested in #CRISPR genome editing, consider coming to my @ETH_en inaugural lecture… https://t.co/FDzOioq3bI
10/7
2019
After years of editing manuscripts electronically, I've resigned myself to the fact that I am far better with a pri… https://t.co/W4vAWnAFsbThe error affected “most or all” of the findings, and the authors have requested a retraction. https://t.co/XsRCAzdB1U
Retweeted by Jacob Corn @wysscoray @ETH_en I haven't had much time to amass @ETH_en swag. Give me another year and I'll match the Skydeck s… https://t.co/VysYJfyh9v
10/2
2019
@Herculien @ETH_en Thanks! She's a blast. And just now starting to crawl. What are we in for!!??I'm hiring postdocs! Do you want to work at the intersection of #CRISPR editing and #DNArepair? Email me your CV an… https://t.co/r4MYGGL73b#SickleCellDisease is the "first genetic disease that was discovered, and wouldn’t it be great if it is also the fi… https://t.co/ySM2i8jVjB
Retweeted by Jacob Cornhttps://t.co/3IwSiYOGWm https://t.co/TAJJOAqTCS
10/1
2019
Do you develop in vivo imaging, cellular flight recorders, or other cutting edge tech to study disease in situ?… https://t.co/NOdlpXQf2VThese Pics Are Composed Of As Many Pixels As There Are Animals Still Alive In These Species https://t.co/InRdEXZRsa https://t.co/7BiIEKaLvQ
Retweeted by Jacob Corn @GaetanBurgio Those bubble plots crack me up. #lognormalwhatsthat
9/30
2019
The DeepMind team (now “Google Health”) developed a model to “continuously predict” AKI within a 48-hr window with… https://t.co/lqFvah5LzN
Retweeted by Jacob Corn @Nicole_Paulk This reminds me that I had an AAV history question for you. Will follow up by email tonight.https://t.co/TU0lhmTr8q https://t.co/9fMv2XlF7b
9/24
2019
It's out! 🥳 We found a new family of defense systems in bacteria, it uses cGAS-like enzymes to generate a signal an… https://t.co/RU0a2ysV03
Retweeted by Jacob Corn
9/19
2019
@meredithmt @theyearofelan I'm a newish dad who once took an 11 hour flight with our 5 month old baby. My wife and… https://t.co/cAinriq7Ne#DNARepair is awesome. @SPJacksonGroup https://t.co/UHk6zqZ1SBA new DSB sensor? Yes, please! https://t.co/dNfycFpXYaMy lab (@bggowen @staciakwyman) had a great time collaborating with David Raulet's group, using #CRISPRi screening… https://t.co/p6KMlrr8E1
9/12
2019
If only we could do an easy human cell line cross. https://t.co/HB43IbPBcr
9/11
2019
Some #savage #whiteboardwisdom for the new week y’all https://t.co/UqYaz0INdE
Retweeted by Jacob Corn
9/9
2019
Asked by MD/PhD students what’s surprised me the most about my academic career so far. Answer: How much I rely on… https://t.co/5I15QzhS6a
Retweeted by Jacob Corn
9/8
2019
@robertietswaart @fiddle Thanks for the clarification! Seems most of the info is caught very well, but I think ther… https://t.co/TfmUrA7Vza @fiddle @fiddle I've noticed that some genes have no GO terms or stats output, even though they were successfully a… https://t.co/b7zSqsesMFWe just tried GeneWalk on some of the lab's #CRISPR screen gene lists. It's like magic! Shared functions that took… https://t.co/nrwTlDTqiH
9/6
2019
Thanks for the #prelight, Nicola! https://t.co/z1w8TBSHhJ
9/2
2019
I'm reading a biography of Catherine the Great. Vividly written and every player comes alive - rare for a historica… https://t.co/sQ26oQXK6O
8/30
2019
This is a very important, carefully done, multi-center study on #CRISPR-ing mice. https://t.co/i2MUf6CMvk
8/26
2019

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